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What is H4CBD? The Ultimate Guide To A New Form Of CBD
Categories: CBD

What is H4CBD? The Ultimate Guide To A New Form Of CBD

Posted: November 03, 2023 | Author: Blog Upload

In this guide we're going to take a detailed look at a cannabinoid called H4CBD, a modified version of the well known and widely available cannabinoid, CBD. H4CBD is pretty new to the market and is currently only available in limited product ranges. We will explore how H4CBD is produced, its effects and how it differs from cannabinoids like, THC, HCC and CBD.

If you're interested in CBD and the latest cannabinoid products like H4CBD, then visit our comprehensive online store where we stock all of the latest and innovative cannabinoid products. At ICE Headshop we pride ourselves on our large range of high quality cannabinoid products and our customer service, so get in touch if you need any further information or assistance.

What is H4CBD?

Most of you are probably aware of the cannabinoid CBD, which is a natural product extracted from cannabis plants and hemp. H4CBD however, is a cannabinoid that has been created by modifying CBD. H4CBD is created by hydrogenating CBD, a process that is commonly likened to the process of making margarine from vegetable oil.

H4CBD was first synthesised by the Todd Group in 1940 during much experimentation with cannabinoids from cannabis plants, and it was discovered in a 2006 study that H4CBD had an affinity for binding to the CB1 receptor.

H4CBD is produced semi-synthetically in a laboratory setting. The reason the process is only semi-synthetic is because CBD is a natural compound and it is modified to create H4CBD by using hydrogen.

The cannabinoid CBD can be synthesised from scratch but this is rarely done as CBD is abundant in cannabis and hemp plants and CBD extract is cheaply and easily obtained. This isn't to say that every product is made with natural CBD; always check the certification of the product or the information provided by the product manufacturer.

How is H4CBD produced?

As mentioned, H4CBD is a modified version of the cannabinoid CBD. It is made by a chemical process that inserts hydrogen atoms into the individually selected molecule. In the case of H4CBD it is four hydrogen atoms that are added. This process alters the properties of the CBD and provides a CBD based product that binds strongly to the CB1 receptors, whereas regular CBD is an antagonist that binds to the receptor indirectly.

The process of hydrogenating CBD is done in a laboratory setting and is a chemical process. Although CBD itself is a natural compound, once hydrogenated it is then a semi-synthetic cannabinoid.

What's the difference between CBD and H4CBD?

The main point of difference is that CBD is the natural and original form of the cannabinoid extracted from cannabis plants, while H4CBD has been modified in a lab to change the profile and effects of the CBD compound.

Anecdotal reports from users of H4CBD have described it as having similar effects of CBD plus psychoactive properties. H4CBD seemingly gives a high but not as intense as that felt from consuming THC, one of the most well-known cannabinoids and one of the main ones responsible for the high feeling associated with cannabis use.

In comparison, CBD itself is known for its potentially relaxing, pain relieving and calming effects without any noticeable psychological effects.

What's the difference between HCC (hydrogenated THC) and H4CBD (hydrogenated CBD)?

The difference between these two compounds is very simple; HCC is a hydrogenated version of THC and H4CBD is a hydrogenated version of CBD. CBD and THC are both found within cannabis plants, each has their own unique properties and can be extracted together or separately.

THC has long been known for its reportedly powerful psychoactive properties and sedative and calming effects as well as many therapeutic benefits. CBD on the other hand has stress relieving, therapeutic and wellness benefits but without any high or stoned feeling.

Another difference is of course the fact that H4CBD is legal in the UK and HCC is not legal in the UK.

Potential effects of the synthetic cannabinoid H4CBD

While there is much scientific research into the properties of CBD and its potential wellness benefits, H4CBD is still in its infancy in terms of what we understand about its benefits and long-term effects. What we do know is that our CB1 receptors are responsible for helping to regulate some of our physiological processes.

The CB1 receptor is responsible for helping regulate physiological processes like:

  • Pain
  • Memory
  • Appetite
  • Inflammation

CBD is an antagonist of the CB1 receptors while H4CBD interacts directly with the CB1 receptors. Some claims are being made that H4CBD works 100x, 1000x better than CBD but this is based purely on its affinity for the CB1 receptors where CBD does not interact directly with our CB1 receptors. More research into the potential benefits of H4CBD is needed as currently there is only one study from 2006 that shows its affinity for CB1 neuroreceptors and potential for anti-inflammatory effects.

What can be said is that, as H4CBD is a modified form of CBD, it may have all of the potential of regular CBD with added effects from the hydrogen atoms.

Does H4CBD get you high?

Anecdotal evidence suggests that H4CBD (a hydrogenated form of CBD) has the effects of conventional CBD with a noticeable stronger feeling. Some are claiming that H4CBD is something in the range of three times stronger than CBD and anywhere up to 100 times stronger but this is certainly difficult to measure and much more research must be done to confirm this.

If you're looking to try H4CBD then you should be aware that you may experience stronger effects that you ordinarily wouldn't feel from natural CBD, which has many beneficial natural properties.

H4CBD products - the best ways to take it

As you may be aware, there are hundreds of interesting and innovative cannabis-based products online available to you. H4CBD is relatively new to the market but manufacturers are already producing high quality H4CBD products including things like vapes and edibles.


Vape products are very popular due to the wide ranges of strengths and flavours available. You will find cannabinoid disposable pens, hundreds of e-liquids, and durable and customisable mod vapes (this means you can modify and change various parts to improve/customise your vaping experience).


Edibles are probably one of the easiest cannabis products to use. Simply pick an edible that matches your strength and flavour preferences and you can take it at home or on the go. Edibles come in all shapes and sizes, so there is sure to be a delicious edible that ticks all of your boxes.

Much like other cannabis products, how you choose to take it is entirely up to you and the best way to take it is the one that suits your day-to-day routine and lifestyle.

Shop our range

At ICE Headshop we have a new range of H4CBD products including vape liquid/e-liquids, H4CBD gummies and also disposable H4CBD vape pens.

It is recommended that when starting a new product you begin with a small dose and build up until you reach your needs. Always follow product guidelines and be sure to check with your medical professional if you have any concerns about effects.

Is H4CBD better than CBD?

Currently, H4CBD is a relatively unexplored cannabinoid, unlike other cannabinoids like THC, CBD and CBG (to name a few). As a derivative of CBD, H4CBD has great potential for wellness and pain relieving effects, as well as things like stress relief, relaxation and aiding restful sleep. More research is yet to be done but in the coming months and years, we will see more high quality H4CBD product lines as well as further research published.

Compared to CBD, H4CBD gives a noticeable high feeling but this doesn't necessarily mean that it is better than CBD, rather, due to its chemical compounds and chemical structure it interacts differently with our cannabinoid receptors and provides a different feeling.

The answer to the question 'Is H4CBD better than CBD' will be different for each individual based on the requirements and preferences for that person's unique needs.

Is H4CBD 100 times stronger than CBD?

Anecdotal claims report H4CBD to be hundreds of times stronger than CBD, some even claim 'a thousand times the potency' but there isn't much evidence to back this up. What we do know is that H4CBD has a high affinity with our CB1 cannabinoid receptor whereas CBD interacts with this receptor as an antagonist and doesn't bind directly. As H4CBD binds with the CB1 receptor it is in fact 100% more efficient at binding to the receptor than CBD but this is no grounds to claim it is 100x stronger.

Legal status of H4CBD

Currently, here in the UK, H4CBD is legal. It sits outside of the Psychoactive Substances Act and also the Misuse of Drugs Act. H4CBD is also legal in most of Europe and also many countries across the world. What is important to keep in mind is that it is your responsibility to check the laws where you live and, if you're travelling to another country, the laws of that country too.

Get in touch

If you are interested in our products or would like to speak to one of our expert team then don't hesitate to get in touch. Our expert team has decades of industry experience and is ready to help you with any of your queries. We very much look forward to hearing from you.

Disclaimer: Please note that you must be 18 years or older to purchase CBD products. All claims and effects of CBD have been regulated by the MHRA since 2016 and distributors require a licence from the MHRA to make any medical claims. Claims are opinion based and non-scientific, and while we may discuss the opinions people share, they are not our own. Our CBD is not intended to treat, cure or prevent disease. Although we can advocate its calming & healthy properties it is in no way intended for medicinal use.